WP2.6

Bioinformatics

The work carried out in this WP involves R&D activities in the field of health sciences in close collaboration with CICS-UBI, including multi-disciplinary projects with topics such as: analysis of biological, clinical and epidemiological data for the identification of disease biomarkers; identification of genomic risk variants in case-control genetic epidemiology studies; computational analysis of genomic variants to assess their potential functional impact; virtual drug screening and drug-molecule interaction modelling; and other computational biology applications.

Team & Collaborators

Publications

Journal articles

(***) Articles published in a top 10% most cited journal of the respective field.

Book Chapters

  • Pissarra I., Marques H., Cruz-Vicente P., Rosado T., Passarinha L., Araujo A., Barroso M., Gallardo E.. (2021). Bioanalytical methods for the determination of antipsychotics and metabolites in biological samples. In Leon V. Berhardt (Eds.) Advances in Medicine and Biology, (pp1-76) Nova Science Publishers, Inc.
  • Antunes M., Simão A., Fonseca S., Gonçalves J., Soares S., Almeida E., Gameiro C., Rosado T., Duarte A., Barroso M., Araújo A., Rodilla J., Gallardo E.. (2020). Liquid chromatography-mass spectrometry as a tool to identify adulteration in different food industries. In Galanakis, C. (Eds.) Food Toxicology and Forensics, (pp 123-180) Academic Press.
  • Antunes M., Simão A., Fonseca S., Gonçalves J., Soares S., Almeida E., Gameiro C., Rosado T., Duarte A., Barroso M., Araújo A., Rodilla J., Gallardo E.. (2020). The Role of CYP2D6 in Opiates and Opioids Consumers and Its Implications in Clinical and Forensic Toxicology. In Leon V. Berhardt (Eds.) Advances in Medicine and Biology, (pp 1-53), Nova Science Publishers, Inc.
  • Simão A., Antunes M., Gonçalves J., Soares S., Castro T., Rosado T., Caramelo D., Barroso M., Araújo A., Rodilla J., Gallardo E.. (2020). The Role of Gas Chromatography in Clinical and Forensic Toxicology. In Henrichon, P. (Eds) Gas Chromatography: History, Methods and Applications, (pp 1-104), Nova Science Publishers, Inc.
  • Gonçalves J., Simão A., Soares S., Gameiro C., Almeida E., Rosado T., Luís Â., Gallardo E., Duarte A.. (2020). Prunus avium L.: Composition, Analysis and Health Benefits. In William Schneider (Eds.) Prunus: Classification, Cultivation and Toxicity, (pp pp1-104), Nova Science Publishers, Inc.
  • Soares S., Gonçalves J., Simão A., Rosado T., Caramelo D., Fernández N., Araújo A., Barroso M., Gallardo E., Lepkowsky C.. (2020). Paroxetine in Human Biological Specimens: A Review of Current Sample Pretreatment and Bioanalytical Approaches. In C. M. Lepkowsky (Eds.) The Pharmacological Guide to Paroxetine, Nova Science Publishers, Inc.

Posters in Conferences

  • Gomes D., Passarinha L., Sousa. A.. (2021). Screening de potenciais inibidores da proteína E6 do HPV para tratamento do cancro do colo do útero. 3º Encontro Nacional de Jovens Investigadores em Oncologia. (virtual conference)
  • Gomes D., Silvestre S., Duarte A., Soares C., Passarinha L., Sousa A.. (2021). Screening of E6 potential inhibitors in cervical cancer. 34th International Papillomavirus Conference. (virtual conference)
  • Gomes D., Passarinha L., Sousa. A.. (2021). In silico and in vitro studies to discover potential E6 inhibitors for cervical cancer. Workshop on Structural Biophysics (Centre National de la Recherche Scientifique), Bordeaux, France.

Oral Presentations

  • Gomes D., Yaduvanshi S., Silvestre S., Duarte A., Santos A., Soares C., Kumar V., Passarinha L., Sousa A.. Compostos naturais como potenciais inibidores da proteína E6: restabelecem a função da p53 induzindo a apoptose em células do cancro do colo do útero. 4º Encontro Nacional de Jovens Investigadores em Oncologia, Porto, Portugal, 2022.

Patents

  • Carvalho J., Lopes-Nunes J., Figueiredo J., Santos T., Miranda A., Riscado M., Sousa F., Duarte A., Socorro S., Tomaz C., Felgueiras M., Teixeira R., Faria C., Cruz C.. Método de deteção molecular do ácido ribonucleico do coronavírus da síndrome respiratória aguda grave 2. Portuguese Patent, 2022. (submitted)

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