Bioinformatics

The work carried out in this WP involves R&D activities in the field of health sciences in close collaboration with CICS-UBI, including multi-disciplinary projects with topics such as: analysis of biological, clinical and epidemiological data for the identification of disease biomarkers; identification of genomic risk variants in case-control genetic epidemiology studies; computational analysis of genomic variants to assess their potential functional impact; virtual drug screening and drug-molecule interaction modelling; and other computational biology applications.

Team & Collaborators

• Ana Paula Duarte | WP leader
• Ana Ramalhinho
• Cláudio Maia
• Manuel C. Lemos
• Sílvia Socorro
• Luiza Granadeiro
• Noel Lopes | Professor, IPG
• Paulo Almeida
• Samuel Silvestre
• Gilberto Alves
• Renato Boto
• Fani Sousa
• Ana Palmeira-Oliveira
• Jorge Gama
• Luísa Amaral
• Elsa Cardoso
• Isabel Tomás Oliveira | Grantee, C4-UBI
• Tiago Rosado | Grantee, C4-UBI

Publications

• Simão, A.Y., Gonçalves, J., Caramelo, D., Rosado, T., Barroso, M., Restolho, J., Fernández, N., Rodilla, J., Duarte, A.P., Cristóvão, A.C., & Gallardo, E. (2020). Determination of N,N-dimethyltryptamine and beta-carbolines in plants used to prepare ayahuasca beverages by means of solid-phase extraction and gas-chromatography–mass spectrometry. SN Appl. Sci. 2, 463.
• Santos, E.S., Luís, Â., Gonçalves, J., Rosado, T., Pereira, L., Gallardo, E., & Duarte, A.P (2020). Julbernardia paniculata and Pterocarpus angolensis: From Ethnobotanical Surveys to Phytochemical Characterization and Bioactivities Evaluation. Molecules 2020, 25, 1828.
• Rosado, T., Gallardo, E., Vieira, D.N., & Barroso, M. (2020). Microextraction by Packed Sorbent as a Novel Strategy for Sample Clean-Up in the Determination of Methadone and Eddp in Hair, Journal of Analytical Toxicology, bkaa040.
• Duarte, A.C., Rosado, T., Costa, A.R., Santos, J., Gallardo, E., Quintela, T., Ishikawa, H., Schwerk, C., Schroten, H., Gonçalves, I., & Santos, C.R.A. (2020) The bitter taste receptor TAS2R14 regulates resveratrol transport across the human blood-cerebrospinal fluid barrier, Biochemical Pharmacology, 2020, 113953.
• Simão, A.Y., Antunes, M., Gonçalves, J., Soares, S., Castro, T., Rosado, T., Caramelo, D., Barroso, M., Araújo, A.R.T.S., Rodilla, J., & Gallardo, E. (2020). The Role of Gas Chromatography in Clinical and Forensic Toxicology. Chapter in Gas Chromatography: History, Methods and Applications. Henrichon, P. (Editor), Analytical Chemistry and Microchemistry.
• Gonçalves, J., Simão, A.Y., Soares, S., Gameiro, C., Almeida, E., Rosado, T., Luís, Â., Gallardo, E., & Duarte, A.P. (2020). Prunus avium L.: Composition, Analysis and Health Benefits. Chapter in Prunus: Classification, Cultivation and Toxicity. Schneider, W. (Editor), Plant Science Research and Practices.
• Soares, S., Gonçalves, J., Simão, A.Y., Rosado, T., Caramelo, D., Fernández, N., Araújo, A.R.T.S., Barroso, M., Gallardo, E., & Lepkowsky, C. M. (2020). Paroxetine in Human Biological Specimens: A Review of Current Sample Pretreatment and Bioanalytical Approaches. Chapter in The Pharmacological Guide to Paroxetine. Lepkowsky, C.M. (Editor), Pharmacology – Research, Safety Testing and Regulation.